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Diagnosed with schizophrenia, Owen is the black sheep of the wealthy Milgrim clan. After losing his job, he enrolls in an experimental drug trial.
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When her pilfered stash of pills runs out, troubled Annie tries to quit – but ends up blackmailing her way into the Neberdine study.
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Muramoto notices irregularities in Annie and Owen's data. He questions Owen, who recalls the worst night of his life: his brother's engagement party.
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After taking the B pill, Annie and Owen find themselves on 1980s Long Island entangled in a strange caper involving a lemur.
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Annie and Owen are Arlie and Ollie, grifters attending a séance at the mysterious Neberdine mansion in the 1940s.
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Azumi tells James the whole truth about the study's snags and urges him to call his estranged mother, an esteemed therapist.
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Owen and Annie take the C pill. No longer connected, he belongs to a Mafia family, and she's a medieval guide hired by an ailing elf princess.
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Annia and Ellia continue their quest, and Owen's mafioso father pressures him to protect the family. Greta counsels a bereaved Gertie.
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Owen and Annie meet again as a disgraced Icelandic spy and a CIA operative who helps him. Greta implores James to shut down the trial.
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After the subjects are discharged, James and Azumi face Neberdine's CEO. Owen and Annie part ways – until a startling headline sparks a reunion.