A man named Brian Finch develops superhuman abilities after taking a mysterious drug called NZT in the series premiere, which finds him landing on the FBI's radar as he works to clear his name of an NZT-related murder.
When Brian helps Agents Harris and Boyle investigate the murder of a retired FBI agent, they're shocked to find a link to the elusive head of a notorious drug cartel. Also, Brian reconnects with an old flame, Shauna but worries her renewed interest is really in the NZT version of him.
Brian's loyalty to the FBI is tested when Sands, Senator Edward Morra's representative, demands he steal the FBI's secret files on NZT. Also, Agent Harris is emotionally conflicted when she learns what her estranged father left her following his death.
Brian learns a shocking secret about Rebecca's late father but worries that telling her will land him in legal trouble. Also, Brian accidentally meddles in Rebecca's personal life while learning self-defense from her secret boyfriend, FBI Agent Casey Rooks.
When Naz is detained on suspicion of funding terrorism, Brian and Rebecca's efforts to clear her name lead them to Naz's daughter, Ava (Michelle Veintimilla), who reveals a family secret Naz is keeping from the FBI.
Brian offers to use NZT to capture the FBI's “Ten Most Wanted” criminals in two weeks, in exchange for Naz giving him his own personal work “headquarters” at the agency. Also, the secretive nature of Brian's new life working for the Bureau creates a rift between him and his father.
When Agent Casey Rooks and his SWAT team skim 80 NZT pills for themselves from the recovery of stolen inventory, it starts an internal investigation that is viewed through the shifting perspectives of Brian's immediate circle at the FBI.
Senator Edward Morra is targeted by a would-be assassin, and Brian is ordered to sabotage the FBI's investigation into the murder attempt in order to prevent exposing the Senator's connection with NZT.
Brian embarks on his first FBI field assignment when he travels to Quantico to lend his skills to the bureau unit that catches serial killers. However, the trip takes a negative turn when Brian realizes the man he's working with may have put away an innocent person in the career-making case that made him a renowned profiler. Also, Brian tries to stay one step ahead of Rebecca as she comes closer to discovering Senator Morra's connection to NZT.
Brian's double life unravels when Senator Morra (Bradley Cooper) makes contact just as Brian's placed under 24-hour surveillance by the FBI following his rogue trip to Russia. Also, Mike and Ike tell an already suspicious Rebecca about Brian's off-book interaction with Morra's henchman, Sands.
When Rebecca learns the truth about her father's death, she takes NZT and uses it to seek justice for his murder; Sands makes a dangerous move against Brian to ensure his success of his new initiative.
When NZT floods the streets of New York City and threatens to become a national epidemic, the FBI partners with the DOJ in a city-wide manhunt to find the lab producing the drug. Also, Brian has trouble adjusting to his new reality when he lacks the resources to continue searching for Piper
Following a stunning betrayal to their team, Brian and the FBI race to stop an NZT-enabled Sands and his associates from orchestrating an international incident. Also, Brian experiences devastating side effects when his NZT immunity starts to wear off.
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