Red continues to battle Berlin and faces a new threat from a man named Lord Baltimore. An important person comes back from the past into Red's world. Meanwhile, Liz tries to move forward with her life after her showdown with Tom.
When the Monarch Douglas Bank is robbed, Red seizes the opportunity to try and take the money-laundering bank down. Liz questions Red's intentions as she investigates the crime. Meanwhile, a new member joins Cooper's taskforce after impressing everyone on the team.
When a man is found with his heart cut out, Agents Keen and Ressler team up with agent Samar Navabi to uncover the intricacies of Dr. Covington's black-market operation. Meanwhile, Red and his associate try to capitalize on a new opportunity in Indonesia, leaving Reddington in a vulnerable position.
After a series of seemingly nonviolent citizens become killers, Red tips off Liz that a dangerous social-psychological experiment may be underway. Elsewhere, Red tries to convince, Naomi and her husband into accepting a complicated proposition.
Agents Keen, Ressler and Cooper pursue an eco-terrorist cell in search of a destructive weapon. Meanwhile, Liz tries to lose her guardian. Elsewhere, Red uses manipulation to pursue someone close to his heart.
When a mutilated corpse washes ashore, Agent Liz Keen consults Red over what he knows about the deadly underworld of wildlife poachers. Meanwhile Agent Donald Ressler develops a dangerous habit.
When an Iranian nuclear scientist is suspiciously assassinated, a revenge ploy begins against a valued American. Red informs agents Keen and Navabi that a dangerously conniving hitman “The Scimitar” has been sent to the job. Liz and Ressler find themselves in a tricky predicament as they investigate a surveillance lead. Agent Keen attempts to gather information on Berlin, while Red finds company with a woman working at a food truck.
Liz struggles to keep her secret from unraveling.
The task force tries to save Red when he's arrested and taken to a secret detention facility. At the facility, Red tangles with a thief with whom he shared a complicated history.
FBI boss Cooper tries to rescue his team in the wake of chaos at a detention facility. Elsewhere, thief Luther Braxton attempts to attain confidential information.
The task force must rescue an undercover CIA agent who was kidnapped by separatists in Uzbekistan; Red thinks they are up against a dangerous past associate known as Ruslan Denisov.
When Red tips Liz off on the disappearance of Justin Kenyon, a polygamous cult leader with dangerous shipping containers buried on his property, the task force sets out to investigate. Meanwhile, Red utilizes his sources to appease Fitch's last words and travels to track down his hidden safe.
When Liz learns of a serial killer known as “The Deer Hunter” who tracks his victims down like prey, Red helps the task force search for the killer. Meanwhile, the local DC police suspect the city Harbormaster was murdered as Liz struggles to keep her secret from unraveling.
A former paramour involves Reddington in a deadly game with a wealthy and powerful family dynasty whose ill-begotten fortune was amassed from an underground auction of human and material contraband. Meanwhile, Tom takes on a new mission.
When Agent Keen is questioned in court as a suspect in the murder of the DC Harbormaster, her unusual relationship with Red and their task force falls under scrutiny. Meanwhile, Red enlists Cooper and Ressler to locate “The Major”, a dangerous former associate who is key in keeping Liz out of prison.
As evidence mounts against Liz in the case of the murdered DC Harbormaster, a federal judge makes it clear to her that she will face severe criminal charges. Reddington and Ressler jump into high gear to exonerate Liz but the only solution is to find the recently vanished Tom Keen - wherever he may be operating in the world.
The task force tracks a scientist who abducts disabled patients to conduct experiments on immortality. Now back in Washington, DC, Tom scrambles to save himself from new enemies.
The task force tracks a provocative female Blacklister (guest star Ana de la Reguera), a frame-up artist who targets the wealthy elite. Tom (Ryan Eggold) pleads for Liz's (Megan Boone) help. Red (James Spader) pressures Liz for the Fulcrum, claiming it's now a matter of life and death.
As Red fights for his life, he pleads with Liz to track down a key figure from his past with knowledge of the Fulcrum.
After decoding the information embedded in the Fulcrum, Red is determined to stop the imminent threat. Meanwhile, the task force discovers that deceased bodies of Chinese-American women are being smuggled out of the country under false identities. Liz continues to search for answers about her past after discovering a picture hidden in Red's secret flat.
Following intel from Red, the FBI find themselves one-step behind the most dangerous Russian Assassin, Karakurt, an enemy on U.S. soil. To avoid catastrophe, Liz and Ressler meet with Russian Counter-Intelligence who offer insight not only on Karakurt, but also on the identity of Liz's mother. Cooper finds himself in a compromising position.
Liz discovers she's been framed by the cabal, prompting Red to tap into his connections to clear her name. Also: Cooper receives stunning news; and the task force is plagued by trust issues.