Jane Doe gets discovered and together with a team of FBI agents, they try to discover her past and who she is.
A tattoo points to an Air Force pilot with a difficult past; a disturbing memory haunts Jane; Weller believes he knows Jane's identity.
A member of a jewel heist crew is caught during a robbery & physical evidence shows he has unknown ties to Jane Doe. Someone from her past visits her but is unable to relay any useful information in time.
Patterson and her puzzle-expert boyfriend, David decode a tattoo clue that sends the team to the Centers for Disease Control (CDC). While at the CDC, the team discovers a hidden message on Jane's body that uncovers a plot that could have catastrophic global consequences. Meanwhile, Jane and Weller grow closer.
After a seemingly straightforward hostage situation turns out to have deeper international implications, the CIA and FBI find themselves racing against each other to apprehend the same criminal with a dark history. Carter expresses concern about Jane's trustworthiness, causing friction with Mayfair and testing Reade's loyalty to the team. Meeting Weller's family proves overwhelming for Jane as she grapples with her identity.
When an assassination leads the team to a dangerous app that allows criminals to track government vehicles, they have to work with the app's surprising creator to take it down. Jane and Weller attempt to keep their relationship professional. Zapata struggles with a moral issue.
One of Jane's tattoos sends the team to a remote location where they find themselves face to face with a dangerous criminal in a case that puts Jane and Weller's strained relationship to the test and threatens to expose Mayfair's secrets. Meanwhile, Patterson breaks the rules to solve a tattoo puzzle.
After a police officer is murdered, Patterson unlocks a disturbing tattoo that appears to have predicted his killing, and the team chases a violent clue trail to stop further attacks. Mayfair reveals secrets from her past to Weller, seriously testing their relationship.
Jane and Weller go undercover as a top-notch assassin couple in order to protect some lethal info. Meanwhile, David tries to repair his relationship with Patterson; and Carter and Mayfair disagree about how to deal with a menacing person.
Sleeper spies get activated and prepare for assassinations so the team rushes to stop them.
Jane reels from a series of massive revelations about her tattoos and grapples with whether to trust Oscar; A tattoo leads the team to a shocking discovery at the Black Sea.
After a disturbed Iraq War vet shoots up a military base, the team exposes a sinister plot. Meanwhile Jane and Weller race to stop a single-minded scientist, as Jane recalls her own mysterious military past and contemplates a new relationship with Oscar.
After a tip reveals a mole within the FBI, the team must hunt for the operative while facing extreme scrutiny from Inspector Fischer; The team's deepest secrets threatened to be exposed and everyone is a potential suspect.
An anonymous tip leads the team to investigate an urgent death row case, sending Zapata undercover; After nearly getting caught during the mole hunt, Jane considers leaving the FBI.
After a painting featuring one of Jane's tattoos is heisted from a gallery, the team discovers Jane is the real target. In order to protect her team, Jane goes AWOL.
After an armored truck is robbed, the team discovers that the stolen goods are chemical weapons and they must race to thwart a terrorist plot; Jane grapples with a confusing memory of Weller; Patterson receives a phone call from someone from her past.
Patterson discovers a hidden message in the New York Times crossword and embarks on a tattoo scavenger hunt that leads her into danger; Oscar finally tells Jane more about who she was.
In order to capture a dangerous international criminal, Jane and Weller are forced to collaborate with the only person he will meet: their former target, Rich DotCom. Jane must decide whether to risk hurting Weller by executing a morally questionable order from Oscar.
When a school shooting breaks out during the investigation of a tattoo, the team splits up to take down the shooter. Mayfair copes with some issues from her past.
When a mysterious young girl with a tattoo connection falls into Borden's care, he brings her case to the FBI team– but her ties to a terrorist organization prove dangerous for all of them. Meanwhile, a conflicted Jane starts to grow close to Weller again, and friendship blossoms between Borden and Patterson.
The FBI is locked down when criminal hackers infiltrate the building, trapping the team inside SIOC. As they fight their way out, the close quarters force Mayfair Zapata, Reade, and Sarah to confront personal conflicts.
After an abandoned baby is found with a tattoo identical to one of Jane's, the team races to piece together the child's identity and save dozens of infants. A furious Jane confronts Oscar about the outcome of his secret missions.
Weller (Sullivan Stapleton) searches for the truth within a heartbreaking and confounding assertion. Jane (Jaimie Alexander) reaches out to a former suspect (guest star Aimee Carrero) for help with Oscar (guest star Francois Arnaud). Meanwhile, the rest of the team struggle to help a friend…