Leonardo and Lorenzo struggle to escape Riario's forces as Florence falls into chaos.
Lorenzo manages to get back to the palace with the help of Da Vinci. Riario whereas continues on the voyage. The Pazzis are hanged for their conspiracy.
Pope Sixtus excommunicates Florence. Lucrezia comes up with a plan to see her imprisoned father. Da Vinci tries to take Duke Alfonso's ship.
Leonardo reunites with Riario and Nico in the New World. Lorenzo attempts to save Florence with the help of an old flame. Clarice struggles to retain control of the Medici Bank.
Lorenzo fights for survival. Leonardo finds out new secrets by going into the Door of Heaven.
Clarice's life is in danger. The fellowship enters the Vault of Heaven, which holds many mysteries and deceptions. Lucrezia reaches her destination, meeting someone along the way.
Leonardo returns to a changed Florence - not all is as it seems. What will become of a changed Riario?
Italy prepares itself for an attack from the Ottomans. Riario is been stalked by danger. Nico is the only person who can control what happens to Vanessa.