Coulson and his team are now wanted fugitives with limited resources - but that's not stopping them from keeping the world safe from powerful and unseen threats everywhere. However, with new members they hardly know, will S.H.I.E.L.D. ever be trusted again?
Hunted and running out of solutions, Coulson puts his team right in the line of fire in the hopes of saving them all. But with General Talbot, Hydra and Creel all on the attack, can they possibly survive? Meanwhile, a mysterious Doctor harbors some dangerous secrets that could destroy one of our core team members.
Coulson and his team race against Hydra to get to Donnie Gill - a dangerous gifted with the ability to freeze objects - while Simmons is caught in the crossfire.
While on a mission to learn more about the secrets of the mysterious writing, Coulson finds himself attacked by the only person he can trust: Agent Melinda May. Meanwhile, the rest of the team is trapped in an explosive situation, and it's up to Fitz to save them - but is he up to it?
Coulson's team is up against the beautiful and deadly Bobbi Morse – Security Chief for Hydra. Meanwhile, Skye's father forces Raina to reunite him with his daughter at any cost.
The world turns against S.H.I.E.L.D. when Hydra impersonates them to attack The United Nations, and an unexpected enemy leads the charge to bring about their downfall.
The team discovers murder victims with the alien glyphs on them that Coulson's been etching. All of Coulson's secrets and lies come to a head on Marvel's Agents of S.H.I.E.L.D.
Coulson and team find themselves in an epic face-off against Hydra to uncover an ancient secret, while Ward kidnaps his brother, Senator Christian Ward, for a violent trip down memory lane.
SHIELD discovers the ancient city before Hydra, but uncovering the secrets may require one of Coulson's team to make the ultimate sacrifice. Meanwhile, May and Skye race to get to Raina before Whitehall takes her.
Whitehall and Coulson's forces take part in an explosive confrontation that changes everyone's fate; Skye uncovers about her past.
Coulson and the team are faced with the consequences of the war with Hydra as revelations threaten to destroy them; Hydra makes a move.
Coulson and the team help Lady Sif, who lost her memory after a fight with a mysterious warrior.
Cal assembles a team of gifted individuals from SHIELD's Index that include Angar the Screamer and KF Gideon, to gain revenge from Coulson. Meanwhile, May calls on her SHIELD ex-husband Dr. Garners therapist and expert on gifted who seems to be able to help Skye on her gift.
Coulson and his team are still reeling from a shocking revelation that leaves the team fractured as they must decide what to do with one of their own. Meanwhile, Bobbi and Mack reveal their true allegiance to Hunter, while elsewhere, Ward and Agent 33 embark on a personal mission
War comes to Coulson's doorstep in a way he never anticipated as shocking revelations are brought to light, and Skye struggles to control her new abilities but will soon make a decision that irrevocably changes her life.
As Robert Gonzalez makes his move, Coulson must do whatever it takes to protect the future of S.H.I.E.L.D. Meanwhile Skye's journey to control her powers take a surprising turn when she meets the enigmatic Inhuman named Lincoln.
The story of Melinda May's transformation into “The Cavalry” is revealed as she finds herself at a crossroads in the war between Coulson and Gonzales. As Skye learns more about her true heritage from Lincoln, the truth about Inhumans will send her in a new direction.
A dangerous new alliance is formed as Coulson and Hunter turn to the last person anyone would expect, Grant Ward! As the war between S.H.I.E.L.D. factions continues, Skye and Lincoln will find themselves drawn into this conflict.
Gonzales and Coulson must find a way to put their differences aside and work together against HYDRA, even if it means teaming up with someone they don't trust.
As tensions rise between S.H.I.E.L.D. and the Inhumans, Skye finds herself torn between the groups; Coulson reveals a secret.
S.H.I.E.L.D puts everything on the line to survive a war that blurs the line between friend and foe. Coulson and his team will be forced to make shocking sacrifices that will leave their relationships and their world changed forever.